Place: Fluid-Structure Interactions in Soft-Matter Systems: From the Mesoscale to the Macroscale, Prato, Italy
Mural thrombosis, due to its highly complex physiological process and its pathological signicance, has gained great attention through mathematical modeling with dierent methods and dierent models. One of crucial aspect of this phenomenon is the eect of cell-cell interaction (CCI) in develop- ment of mural clot, which is inherited from complexity of blood via dierent suspended cells. In this work, we have implemented dissipative particle dy- namics, to model ow of plasma, biconcave RBCs, and platelets in proximity of a 24rc mural lesion in middle of a 2D micro-channel of (150rc 80rc) with a parabolic inlet. The CCI is mainly gained through grouping of DPD particles within each cell which interact with the uid particles and other cells in addition to the use of elastic collision theory [1,2]. To emphasis the CCI eect we have compared two models of thrombosis: one including only platelets ow, and in the other RBCs and platelets are both included. In this comparison, the eect of RBC-platelet interaction is vivid in both increasing the rate of aggregation and the proximal fraction of the aggregated platelets along the lesion which agree well with the previous in-vitro and numerical studies [3,4]. As a concluding remark, the explicit modeling of suspended cells in blood ow helps in gaining better view on the clot formation process.
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