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In this contribution a novel approach for simulating cancellous bone is proposed. It is based on the application of the multiscale finite element method (FEM) and requires a careful choice of the appropriate representative volume element (RVE). This task is here especially challenging as cancellous bone includes a solid and a fluid phase which requires dynamic analysis. In our model shell elements for the solid phase, and brick 8-nodes elements for the narrow part are used. Testing the chosen RVE yields the effective material tensor which is illustrated by a numerical example. © 2010 Taylor & Francis Group, London.