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In this contribution an approach for the modeling of the mechanical behavior of arterial walls under supra-physiological loading conditions is investigated. One example of an overstretched atherosclerotic artery is provided using a finite element simulation. Therefor, the constitutive model from [1] is utilized, which reflects the anisotropic material behavior as well as damage-induced softening. This model is adjusted to the uniaxial stress response of the media and adventitia of human abdominal aortic specimens [7] for untreated control samples (with collagen and elastin intact) as well as for elastase- and collagenase-treated samples, leaving elastin-free and collagen-free tissue behind, respectively. © 2014 by Walter de Gruyter Berlin Boston.